Evaluation of Curcumin, Piperine, and Ferrous Sulphate Combination Potential in the Adjuvant-induced Arthritis Model in Male Wistar Rats

Pharmacognosy Research,2022,14,4,483-491.DOI:10.5530/pres.14.4.70Published:October 2022Type:Original ArticleAuthors:Ami Thakkar, Nirav Bhatia, and Gaurav Doshi Author(s) affiliations:Ami Thakkar1, Bhatia2, Doshi2,* 1Department of Pharmaceutical Analysis, Shobhaben Pratapbhai Patel School Pharmacy Technology Management, Vile Parle, Mumbai, Maharashtra, INDIA. 2Department Pharmacology, SVKM’s Dr. Bhanuben Nanavati College Pharmacy, Abstract:Background: Rheumatoid arthritis (RA) is an autoimmune disorder known for prolonged joint inflammation deformity condition. Currently, Complementary alternative medicine (CAM) treatment in RA patients preferred. Objectives: The research focuses on exploring the combination (curcumin (200mg/kg), piperine (10mg/kg), ferrous sulphate (0.1mg/kg) potential adjuvant-induced model (AIA) compared with disease control prednisone acetate (standard 5 mg/kg) (AIA). Materials Methods: Male Wistar rats each group was treated standard, curcumin, piperine, individually as well 28 days after induction arthritis. Evaluation parameters were body weight, paw edema, mobility condition, stair climbing test. Furthermore, Red Blood Cells (RBCs), White (WBCs), immune organ index (spleen thymus) elucidated. study concluded histopathology, X-ray radiography, Tumour Necrosis Factor α (TNF α), Interleukin- 1beta (IL-β) examination. Results: showed significance gradual increase weight (7th day), whereas conditions edema found effective (28th day). RBC WBC counts to be clinically significant. highly significant estimation index. Combination change infiltration inflammatory cells, space, minimal erosion bone indicating satisfactory anti-arthritic effects. improvement radiodensity narrowing space. level TNF-α IL-1β Conclusion: antiinflammatory activity. Keywords:Adjuvant-induced (AIA), Complete Freud’s adjuvant, (IL-β), Arthritis, Spleen, ThymusView:PDF (1.56 MB)